Polypeptides and nucleic acids associated with cancer

Details Polypeptides and nucleic acids associated with cancer Polypeptides and nucleic acids associated with cancer

2005-07-19

2005-07-19

Ungar, Susan (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C435S094000, C536S023100, C536S024300, C536S024310, C536S024330, C530S350000

Reexamination Certificate

active

06919176

ABSTRACT:
The present invention provides methods, reagents, and kits for diagnosing and treating cancer in a mammal, e.g., a human. This invention is based upon the discovery that G2A, GPR4, GPR65, and OGR1 are overexpressed and/or amplified in cancer. Methods to detect cancer or a propensity to develop cancer, to monitor the efficacy of a cancer treatment, and to treat cancer, by inhibiting the expression and/or activity of G2A, GPR4, GPR65, and OGR1 in a cancer cell are included.

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