Polypeptides and methods for the detection of L. tropica infecti

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241841, 4242681, 530300, 530350, A61K 3800, A61K 39002, C07K 200, C07K 1400

Patent

active

059651423

ABSTRACT:
Compounds and methods for diagnosing Leishmania tropica infection, or for screening for L. tropica infection, are disclosed. The disclosed compounds are polypeptides that contain one or more epitopes of an L. tropica protein, Lt-210. The compounds are useful in a variety of in vitro and in vivo immunoassays for detecting L. tropica infection. The polypeptides are further useful in vaccines and pharmaceutical compositions for preventing leishmaniasis in individuals exposed to L. tropica.

REFERENCES:
patent: 4992273 (1991-02-01), Monjour et al.
Campos-Nato et al, 1995, J. Exp. Med. 182: 1423-33.
Magill et al, 1992, JAMA, 267(11):1444-1446.
Jaffe et al, 1990. Clin. Exp. Immunol, 80:77-82.
Wilson et al, 1996, Gastroenteral Clin. of North Am., 25(3): 535-51.
Webb et al, 1996, J. Immunol., 157: 5034-5041.
Gardiner et al, 1983, Mol & Biochem Parasitol., 8:283-95.
Dillon et al, 1995, PNAS, 92: 7981-7985.
Howard et al, 1982, J of Immunol, 129(5):2206-2212.
Michiels et al, 1994, J. Oral Pathol. Med. 23:45-46.
Green et al, 1983, Trans. Roy. Soc. Trop. Med. & Hyg., 77(2):152-9.
Maul et al, 1982. Immunology of Parasitic Infection 2nd edition pp. 299-355.
Da Costa et al, 1996. Am. J. Trop. Med. Hyg., 55(5):511-515.
Webb et al, 1991. Mol. & Brochem. Parasitol, 48:173-184.
Yasir Skreiky et al., Antigens Shared by Leischmania Species and Trypasnosoma cruzi: Immunological Comparison of the Acidic Ribosomal P0 Proteins, Infection and Immunity 62:5, 1643-1651, 1994.
Manuel Soto et al., Isolation, characterization and analysis of the expression of the Leishmania ribosomal PO protein genes, Molecular and Biochemical Parasitology 61, 265-274, 1993.
Soto et al., Genomic Organization and Expression of Two Independent Gene Arrays Coding for Two Antigenic Acidic Ribosomal Proteins of Leishmania, J. of Biological Chem. 268:29, 21835-43,1993.
Yasir Skeiky et al., Cloning and Expression of Trypanosoma cruzi Ribosomal Protein P0 and Epitope Analysis of Anti-P0 Autoantibodies in Chagas' Disease Patients, J. Exp. Med. 176, 201-211, 1992.
James M. Burns, Jr. et al., Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis, Proc. Natl. Acad. Sci. 90, 775-779, 1993.
Skeiky et al., A Recombinant Leishmania Antigen that Stimulates Human Peripheral Blood Mononuclear Cell to Express a Th1-Type Cytokine Profile and to Produce Interleukin 12, Journal of Experimental Medicine 181:4, 1527-1537, 1995.
Skeiky et al., Proliferative and Cytokine Responses of Human PBMC to Cloned Leishmania Braziliensis Heat Shock and Ribosomal Antigens, Journal of Immunology 150(8pt. 2):93A, Abstract #517, 1993.
Shapira et al., Sequence analysis and transcriptional activation of heat shock protein 83 of Leischmania mexicana amazonensis, Molecular and Biochemical Parasitology 42:2, 247-255, 1990.
Mongneau et al., Expression Cloning of a Protective Leishmania Antigen, Science 268, 563-566, 1995.
De Andrade et al., Recombinant Leishmania Hsp90 and Hsp70 are Recognized by Sera from Visceral Leishmaniasis Patient but not Chagas' Disease Patients, J. of Clinical Microbiology 30:2, 330-5, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polypeptides and methods for the detection of L. tropica infecti does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptides and methods for the detection of L. tropica infecti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptides and methods for the detection of L. tropica infecti will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-649495

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.