Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Reexamination Certificate
2004-12-31
2010-10-19
Devi, S. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
C424S185100, C424S184100, C514S002600, C530S350000, C530S823000
Reexamination Certificate
active
07815918
ABSTRACT:
A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-lengthPneumocystiskexin, or a full lengthStreptococcus pneumoniaepneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by aPneumocystisorganism, in a patient.
REFERENCES:
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patent: 95/23513 (1995-09-01), None
patent: WO 98/39424 (1998-09-01), None
Gigliotti et al., “Passive Intranasal Monoclonal Antibody Prophylaxis Against MurinePneumocystis cariniiPneumonia,” Infection and Immunity 70(3):1069-1074 (2002).
Lee et al., “Molecular Characterization for KEX1, a Kexin-like Protease in MousePneumocystis carinii,” Gene 242:141-150 (2000).
Wells et al., “Epitope Mapping of a Protective Monoclonal Antibody AgainstPneumocystis cariniiWith Shared Reactivity toStreptococcus pneumoniaeSurface Antigen PspA,” Infection and Immunity 72(3):1548-1556 (2004).
Supplemental Partial European Search Report for European Patent Application No. EP04815948 (Jul. 22, 2009).
Gigliotti Francis
Haidaris Constantine G.
Simpsonhaidaris Patricia J.
Wells Jesse
Wright Terry W.
Devi S.
Nixon & Peabody LLP
University of Rochester
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