Polypeptides and derivatives thereof as well as their use in pha

Details Polypeptides and derivatives thereof as well as their use in pha Polypeptides and derivatives thereof as well as their use in pha

1988-12-21

1992-10-13

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 92, 530324, 530325, 530326, 530327, 530328, 530330, 530345, 530405, 514 12, 514 13, 514 14, 514 15, 514 21, 435188, 435207, A61K 39385, A61K 3904, A61K 3712, C07K 706

Patent

active

051549239

ABSTRACT:
A polypeptide having amino acid sequence 172-192 of a Mycobacterium bovis BCG 64 kD polypeptide, said sequence having the formula ##STR1## as well as polypeptides derived therefrom, in the amino acid sequence of which sequence 172-179 and/or sequence 189-192 is (are) entirely or partially absent, were found to be useful as immunogens inducing resistance to auto-immune arthritis and similar auto-immune diseases.
The invention relates to these polypeptides, to polypeptides showing sequential homology with these polypeptides, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer form part of the invention.
Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.

REFERENCES:
patent: 4689397 (1987-08-01), Shinnick et al.
patent: 4772685 (1988-09-01), Schmidt et al.
patent: 4777239 (1988-10-01), Schoolnik et al.
patent: 4857634 (1989-08-01), Minor et al.
Rudinger in J. A. Parsons ed Peptide Horone Univ. Park Press Baltimore Jun. 1976 pp. 1-7.
Shinnick (1987) J. Bacteriol 169(3):1080-1088.
Shinnick et al. (1987) Infecet. Immunity 55(8):1932-1935.
Brief Definitive Report-A Recombinant 64 Kioldalton Protein of Mycobacterium bovis Bacillus Calmetter Cuerin Specifically Stimulates Human T4 Clones Reactive to Mycobacterial Antigens by Emmrich et al. pp. 1025-1029.
Evidence for an HLA-DRA4-Associated Immune--Response Gene For Mycobacterium Tuberculosis-A Clue to the Pathogenesis of Rheumatoid Arthritis? By Tome H. M. Ottenhoff et al. pp. 310-313--The Lancet Aug. 9, 1986
Dissection of Mycobacterium tuberculosis antigens using recombinant DNA. By Richard A. Young et al., Proc. Natl. Acad. Sci USA vol. 82 pp. 2583-2587 May, 1989--Biochemistry.
Vol. 105, 1986 p. 525 Chem Abstracts, Abst. #151096y.
Cloning of Mycobacterium bovis BCG DNA and Expression of Antigens in Escherichia coli Jelle E. R. Thole et al. Received Jun. 17, 1985 Accepted Sep. 3, 1985 pp. 800-806 vol. 50 No. 3.
Characterization, sequence Determination and Immunogenicity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed in Escherichia coli K-12 by Thole et al. vol. 55 No. 6 received Nov. 21, 1986 accepted Feb. 23, 1987, pp. 1466-1475.
The Etiologic Agents of Leprosy and Tuberculosis Share an Immunoreactive Protein Antigen with the Vaccine Strain Mycobacterium bovis BCG by Thole et al. Infection and Immunity Aug. 1987, pp. 1932-1935.
Chemical Abstracts vol. 103 (1985) Abstract No. 69497e, M. J. Darsley et al.

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