Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-04-03
1998-11-10
Sidberry, Hazel F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530300, 530324, 530325, 530326, 435 71, 435 73, 435 691, 435 693, 435 711, 4242421, 4242491, 4242501, C07K 1422, G01N 3353, G01N 33569, G01N 33571
Patent
active
058345914
ABSTRACT:
The present invention provides a novel protein of pathogenic forms of Neisseria, as well as genes which encode PilC, i.e., the pilC loci. DNA sequences of pilC genes are useful as probes to diagnose the presence of microorganisms containing type 4 pilin as well as permitting production of polypeptides which are in turn useful in diagnostic tests and/or as components of vaccines. The invention also provides antibodies directed against pilC epitopes. These antibodies are useful for diagnostic tests as well as therapy.
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Nunn D., et al., "Products of three accessory genes, pilB, pilC, and pilD, are required for biogenesis of Pseudomonas aeruginosa pili", Journal of Bacteriology (1990) 172(6):2911-2919.
Perry A., et al., "Neisseria meningitidis C114 contains silent, truncated pilin genes that are homologous to Neisseria gonorrhoeae pil sequences", Journal of Bacteriology (1988) 170(4):1691-1697.
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New England Biolabs Catalog (1986/87), New England Biolabs Inc., Beverly, Massachusetts, p. 60.
Sigma Chemical Company Catalog (1990), Sigma Chemical Company, St. Louis, Missouri, pp. 859-860.
Meyer T., et al., "Pilus genes of Neisseria gonorrhoeae: Chromosomal organization and DNA sequence", Proceedings of the National Academy of Sciences (1984) 81:6110-6114.
Tinsley C., et al., "Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of meningococcal infection", Journal of General Microbiology (1986) 132:2483-2490.
Kellogg et al, "Neiseria gonorrhoeae: II. Colonial variation and pathogenicity during 35 months in vitro", J. Bacteriology (1968) 96:596-605.
Pearce et al., "Attachment role of gonococcal pili: Optimum conditions and quantitation of adherence of isolated pili to human cells in vitro", J. Clinical Investigation (1978) 61:931-943.
Swanson, "Studies on gonococcus infection: IV Pili: their role in attachment of gonococci to tissue culture cells", J. Experimental Medicine (1973) 137:571-589.
Jonsson A.B., "Identification and Cloning of a kD Outer Mmebrane Protein of Neisseria Gonorrhoeae Enriched in Pili Preparations", Abstracts from the 90th Annual Meeting of the American Society of Microbiology (1990) B-17, p. 29.
Tramont, E.C., et al., "Parenteral conococcal Pilus Vaccine" in The Pathogenic Neisseriae: the Proceedings of the Fourth International Symposium, (Asilomar, California, USA, 21-25 Oct. 1984); Eds. Gary K. Schoolnik et al., published by the American Society for Microbiology, Washington, D.C., 1985.
Swanson, "Studies on gonococcus infection: IV. Pili: their role in attachment of gonococci to tissure culture cells", J. Experimental Medicine (1973) 137:571-589.
Pearce et al., "Attachment role of gonococcoal pili: Optimum conditions and quantitation of adherence of isolated pili to human cells in vitro", J. Clinical Investigation (1978) 61:931-943.
Kellogg et al, "Neisseria gonorrhoeae: II. Colonial variation and pathogenicity during 35 months in vitro", J. Bacteriology (1968) 96:596-605.
Swaney, L., et al., "Genetic complementation analysis of Escherichia coli type 1 somatic pilus mutants", Journal of Bacteriology (1977) 130(1):506-511.
Nunn D., et al., "Products of three accessory genes, pilB, pilC, and pilD, are requred for biogenesis of Pseudomonas aeruginosa pili", Journal of Bacteriology (1990) 172(6):2911-2919.
Perry A., et al., "Neisseria meningitidis C114 contains silent, truncated pilin genes that are homologous to Meisseria gonorrhoear pil sequences", Journal of Bacteriology (1988) 170(4):1691-1697.
Kelley W., et al., "A rapid procedure for isolation of large quantities of Escherchia coli DNA polymerase I utilizing a .gamma.polA transducing phage", Journal of Biological Chemistry (1979) 254(9):3206-3210.
Haas R., et al., "Release of soluble pilin antigen coupled with gene conversion in Neisseria gonorrhoeae", Proceedings of the National Academy of Sciences (1987) 84:9079-9083.
Meyer T., et al., "Plus genes of Neisseria gonorrheae: Chromosomal organizatin and DNA sequences", Proceedings of the National Academy of Sciences (1984) 81:6110-6114.
Tinsley C., et al., "Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of meningococcal infection", Journal of General Microbiology (1986) 132:2483-2490.
Jonsson Ann-Beth
Normark Staffan
Sidberry Hazel F.
Washington University
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