Polypeptides and antibodies derived from GAP associated protein,

Details Polypeptides and antibodies derived from GAP associated protein, Polypeptides and antibodies derived from GAP associated protein,

1991-05-17

1997-03-11

Houtteman, Scott W.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530352, 5303871, C07K 1400, C07K 14435

Patent

active

056102763

ABSTRACT:
The subject invention provides for nucleotide sequences encoding polypeptide p62 and derivatives thereof. Another aspect of the subject invention also provides for methods of purifying p62 and derivatives thereof from cells naturally producing p62 and from cells genetically modified so as to produce p62.
The subject invention also provides for methods of assaying tyrosine kinase activity by means of measuring the phosphorylation of p62 and p62 derivatives. Measurement of p62/p62 derivative phosphorylation may be used to determine whether or not a call is cancerous.

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