Polypeptides

Details Polypeptides Polypeptides

1993-11-17

1998-06-16

Grimes, Eric

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352542, 435325, 530363, C07K 14765, C07K 1900, C12N 510, C12P 2100

Patent

active

057668833

ABSTRACT:
A fusion polypeptide comprising, as at least part of the N-terminal portion thereof, an N-terminal portion of HSA or a variant thereof and, as at least part of the C-terminal portion thereof, another polypeptide except that, when the said N-terminal portion of HSA is the 1-n portion where n is 369 to 419 or a variant thereof then the said polypeptide is one of various specified entities.
The HSA-like portion may have additional N-terminal residues, such as secretion leader sequences (signal sequences). The C-terminal portion is preferably the amino terminal fragment of human urokinase-type plasminogen activator. The N-terminal and C-terminal portions may be cleavable to yield the isolated C-terminal portion, with the N-terminal portion having served to facilitate secretion from the host. Such cleavage can be achieved in yeast using a sequence cleavable by the KEX2 protease of S. cerevisiae.

REFERENCES:
patent: 4751180 (1988-06-01), Cousens et al.
patent: 5302697 (1994-04-01), Goodey et al.
patent: 5380712 (1995-01-01), Ballance et al.
Hitzeman et al., Meth. Enzymol. 185:421-440, 1990.
Hedgpeth et al. Proc. Natl. Acad. Sci. vol. 77 (5) pp. 2621-25 (1980).

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