Polypeptide with reduced allergenicity

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

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530350, 530403, 435189, 435190, C07K 110

Patent

active

061145092

ABSTRACT:
The invention relates to modified polypeptides with reduced allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a molecular weight (M.sub.r) in the range of 1 kDa and 60 kDa. The modified polypeptide are produced using a process including the step of conjugating from 1 to 30 polymer molecules with the parent polypeptide. Further the invention relates to compositions comprising said polypeptides and further ingredients normally used in e.g. detergents, including dishwashing detergents and soap bars, household article, agrochemicals, personal care products, cosmetics, toiletries, oral and dermal pharmaceuticals, composition for treating textiles, and compositions used for manufacturing food and feed. Finally the invention is directed to uses of polypeptides with reduced allergenicity or compositions thereof for reducing the allergenicity of products for a vast number of industrial applications.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 5080891 (1992-01-01), Saifer et al.
patent: 5133968 (1992-07-01), Nakayama et al.
patent: 5230891 (1993-07-01), Nakayama et al.
patent: 5856451 (1999-01-01), Olsen et al.
patent: 5981718 (1999-11-01), Olsen et al.

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