Polypeptide variants with increased heparin-binding capacity

Details Polypeptide variants with increased heparin-binding capacity Polypeptide variants with increased heparin-binding capacity

2007-08-07

2007-08-07

Allen, Marianne P. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000, C530S351000, C536S022100, C536S023100, C536S023510

Reexamination Certificate

active

09913467

ABSTRACT:
The invention pertains to polypeptide variants with increased heparin-binding ability. Increased heparin-binding ability is achieved by addition, insertion, and/or substitution of an amino acid sequence X1X2X3X4X5X6(SEQ ID NO. 1 or NO.2). Polypeptide variants according to the invention are particularly suited for stimulation of chondrogenesis, osteogenesis, and wound healing. The invention also pertains to amino acid molecules that encode said polypeptide variants, host cells containing said nucleic acid molecules, and processes for producing the polypeptide variants.

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