Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2008-05-13
2008-05-13
Haddad, Maher M. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S388100, C530S388150, C530S388230
Reexamination Certificate
active
07371826
ABSTRACT:
The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
REFERENCES:
patent: 4490473 (1984-12-01), Brunhouse
patent: 4752601 (1988-06-01), Hahn
patent: 5204244 (1993-04-01), Fell et al.
patent: 5348876 (1994-09-01), Michaelsen et al.
patent: 5419904 (1995-05-01), Irie
patent: 5576184 (1996-11-01), Better et al.
patent: 5624821 (1997-04-01), Winter et al.
patent: 5648260 (1997-07-01), Winter et al.
patent: 5698449 (1997-12-01), Baumann et al.
patent: 5730977 (1998-03-01), Ooka et al.
patent: 5731168 (1998-03-01), Carter et al.
patent: 5736137 (1998-04-01), Anderson et al.
patent: 5834597 (1998-11-01), Tso et al.
patent: 5985599 (1999-11-01), McKenzie et al.
patent: 6136310 (2000-10-01), Hanna et al.
patent: 6165745 (2000-12-01), Ward et al.
patent: 6194551 (2001-02-01), Idusogie et al.
patent: 6242195 (2001-06-01), Idusogie et al.
patent: 6277375 (2001-08-01), Ward
patent: 6491916 (2002-12-01), Bluestone et al.
patent: 6528624 (2003-03-01), Idusogie et al.
patent: 6538124 (2003-03-01), Idusogie et al.
patent: 6676927 (2004-01-01), Ravetch
patent: 6706265 (2004-03-01), Bolt et al.
patent: 6737056 (2004-05-01), Presta
patent: 6821505 (2004-11-01), Ward
patent: 7083784 (2006-08-01), Dall'Acqua et al.
patent: 7122637 (2006-10-01), Presta
patent: 7183387 (2007-02-01), Presta
patent: 2001/0036459 (2001-11-01), Ravetch
patent: 2002/0098193 (2002-07-01), Ward
patent: 2003/0158389 (2003-08-01), Idusogie et al.
patent: 2003/0166868 (2003-09-01), Presta et al.
patent: 2003/0190311 (2003-10-01), Dall'Acqua et al.
patent: 2004/0002587 (2004-01-01), Watkins et al.
patent: 2004/0191244 (2004-09-01), Presta
patent: 2004/0191265 (2004-09-01), Schenerman et al.
patent: 2004/0228856 (2004-11-01), Presta
patent: 2005/0118174 (2005-06-01), Presta
patent: 2005/0233382 (2005-10-01), Presta
patent: 2006/0067930 (2006-03-01), Adams et al.
patent: 2006/0194290 (2006-08-01), Presta
patent: 2006/0194291 (2006-08-01), Presta
patent: 2006/0194954 (2006-08-01), Idusogie et al.
patent: 2006/0194957 (2006-08-01), Presta
patent: 2006/0246004 (2006-11-01), Adams et al.
patent: 2007/0009523 (2007-01-01), Presta
patent: WO 88/07089 (1988-09-01), None
patent: WO 93/22332 (1993-11-01), None
patent: WO 94/29351 (1994-12-01), None
patent: WO 97/28267 (1997-08-01), None
patent: WO 97/34631 (1997-09-01), None
patent: WO 97/44362 (1997-11-01), None
patent: WO 98/23289 (1998-06-01), None
patent: WO 98/52975 (1998-11-01), None
patent: WO 99/43713 (1999-09-01), None
patent: WO 99/51642 (1999-10-01), None
patent: WO 99/58572 (1999-11-01), None
patent: WO 00/09560 (2000-02-01), None
patent: WO 00/42072 (2000-07-01), None
patent: WO 01/58957 (2001-08-01), None
patent: WO 02/060919 (2002-08-01), None
patent: WO 2004/004662 (2004-01-01), None
patent: WO 2004/029207 (2004-04-01), None
patent: WO 2004/035752 (2004-04-01), None
patent: WO 2004/063351 (2004-07-01), None
patent: WO 2004/092219 (2004-10-01), None
patent: WO 2004/099249 (2004-11-01), None
patent: WO 2005/037867 (2005-04-01), None
Mikayama et al. PNAS 1993, 90:10056-10060.
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Allan and Isliker, “Studies on the complement-binding site of rabbit immunoglobulin G-I. Modification of tryptophan residues and their role in anticomplementary activity of rabbit IgG”Immunochemistry11(4):175-180 (Apr. 1974).
Angal et al., “A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human (IgG4) antibody”Molecular Immunology30(1):105-108 (Jan. 1993).
Antibodies. A Laboratory Manual, Harlow and Lane, New York:Cold Spring Harbor Laboratory pp. 321 (1988).
Armour et al., “Recombinant Human IgG Molecules Lacking Fcγ Receptor I Binding and Monocyte Triggering Activities”European Journal of Immunology. 29(8):2613-2624 (1999).
Artandi et al., “Monoclonal IgM rheumatoid factors bind IgG at a discontinuous epitope comprised of amino acid loops from heavy-chain constant-region domains 2 and 3”Proc. Natl. Acad. Sci. USA89(1):94-98 (Jan. 1, 1992).
Bloom et al., “Intrachain disulfide bond in the core hinge region of human IgG4”Protein Science6:407-415 (1997).
Bolland et al., “SHIP modulates immune receptor responses by regulating membrane association of Btk”Immunity8(4):509-516 (Apr. 1998).
Bredius et al., “Role of neutrophil FcγRIIa (CD32) and FcγRIIIb (CD16) polymorphic forms in phagocytosis of human IgG1- and IgG3-opsonized bacteria and erythrocytes”Immunology83(4):624-630 (Dec. 1994).
Brekke et al., “Human IgG Isotype-Specific Amino Acid Residues Affecting Complement-Mediated Cell Lysis and Phagocytosis.”European Journal of Immunology24(10):2542-2547 (Oct. 1994).
Burmeister et al., “Crystal Structure of the Complex of Rat Neonatal Fc Receptor with Fc.”Nature372(6504):379-383 (Nov. 24, 1994).
Burton and Woof, “Human Antibody Effector Function”Advances in Immunology51:1-84 (1992).
Burton et al., “Molecular recognition of antibody (IgG) by cellular Fc receptor (FcRI)”Molecular Immunology25(11):1175-1181 (1988).
Burton et al., “The Clq Receptor Site on Immunoglobulin G.”Nature288(5789):338-344 (Nov. 27, 1980).
Burton, D.R., “Immunoglobulin G: Functional Sites”Molecular Immunology22(3):161-206 (1985).
Canfield and Morrison, “The Binding Affinity of Human IgG for its High Affinity Fc Receptor is Determined by Multiple Amino Acids in the CH2 Domain and is Modulated by the Hinge Region.”J. Experimental Medicine173(6):1483-1491 (Jun. 1, 1991).
Capel et al., “Heterogeneity of Human IgG Fc Receptors”Immunomethods4:25-34 (1994).
Capon et al., “Designing CD4 Immunoadhesins for AIDS Therapy”Nature337:525-531 (Feb. 9, 1989).
Carter et al., “Humanization of an Anti-p185HER2Antibody For Human Cancer Therapy”Proc. Natl. Acad. Sci. USA89(10):4285-4289 (May 1992).
Chappel et al., “Identification of Secondary FcγRI Binding Site within a Genetically Engineered Human IgG Antibody”Journal of Biological Chemistry268:25124-25131 (1993).
Chappel et al., “Identification of the Fcγ Receptor Class I Binding Site in Human IgG Through the use of Recombinant IgG1/IgG2 Hybrid and Point-Mutated Antibodies.”Proc. Natl. Acad. Sci. USA88(20):9036-9040 (Oct. 15, 1991).
Clynes and Ravetch, “Cytotoxic antibodies trigger inflammation through Fc receptors”Immunity3(1):21-26 (Jul. 1995).
Clynes et al., “Fc Receptors Are Required in Passive and Active Immunity to Melanoma”Proc. Natl. Acad. Sci. USA95(2):652-656 (Jan. 1998).
Clynes et al., “Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors”Journal of Experimental Medicine189(1):179-185 (Jan. 4, 1999).
Clynes et al., “Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis”Science279(5353):1052-1054 (Feb. 13, 1998).
Cosimi, A.B., “Clinical Development of ORTHOCLONE OKT3”Transplantation Proceedings(Suppl 1) XIX(2):7-16 (Apr. 1987).
Daeron, M., “Fc Receptor Biology”Annual Review of Immunology15:203-234 (1997).
de'Haas et al., “Fcγ Receptors of Phagocytes”J. of Laboratory Clinical Medicine126:330-341 (Oct. 1995).
Deisenhofer, J, “Crystallographic Refinement and Atomic Models of a Human Fc Fragment and Its Complex with Fragment B of Protein A fromStaphylococcus aureusat 2.9- and 2.8-A Resolution”Biochemistry20(9):2361-2370 (1981).
Duncan and Winter, “The Binding Site for Clq on IgG.”Nature332:738-740 (Apr. 21, 1988).
Duncan et al., “Localization of the Binding Site for the Human High-Affinity Fc Receptor on IgG.”Nature3
Crowder Chun
Genentech Inc.
Haddad Maher M.
Lee Wendy M.
LandOfFree
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