Polypeptide useful for the preparation of antimalarial vaccines

Details Polypeptide useful for the preparation of antimalarial vaccines Polypeptide useful for the preparation of antimalarial vaccines

1991-12-04

1993-07-06

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

424 88, 530325, 530326, C07K 710

Patent

active

052255301

ABSTRACT:
Polypeptide useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies in clinical samples of malariated persons, constituted by: a synthetic peptide, which repeates the region I of P. falciparum and by a variable number of repetitive tetrapeptide units of CS protein of P. falciparum linked to each other by an amidic bond between the tail proline of I region and the head asparagine of the first tetrapeptide.

REFERENCES:
patent: 4693994 (1987-09-01), McCutchan et al.
patent: 4707357 (1987-11-01), Dame et al.
patent: 4886782 (1989-12-01), Good et al.
patent: 4997647 (1991-03-01), Nussenzweig et al.
Stewart and Young, Solid Phase Peptide Synthesis, 2nd ed., Pierce Chemical Co., 1984, pp. 1-18, 99-103.
Zavala, et al., Science, 228:1436, 1985.
Perspectives in Peptide Chemistry, pp. 101-117 (Karger, Bosel 1981).
JACS Chem. Comm., 1978, pp. 537-539.

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