Polypeptide tumor inhibitors and antibodies thereto

Details Polypeptide tumor inhibitors and antibodies thereto Polypeptide tumor inhibitors and antibodies thereto

1985-01-25

1987-12-22

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

436548, 436804, 530300, 530324, 530326, 530328, 530329, 530330, 530350, 530387, G01N 3353, G01N 33534, G01N 33577, G01N 3368

Patent

active

047146834

ABSTRACT:
Polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.

REFERENCES:
patent: 4428875 (1984-01-01), De Barbieri
patent: 4457867 (1984-07-01), Ishida
patent: 4529594 (1985-07-01), Hayashi
Guidotti, A. et al., Nature, 275 (5680), 553-555 (Oct. 12, 1978).
Chemical Abstracts, I, 94:76605m (1981).
Chemical Abstracts, II, 98:83311z (1983).

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