Polypeptide, the conjugate thereof with doxorubicine and a...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S002600, C530S300000, C530S327000, C530S345000, C536S016800

Reexamination Certificate

active

07368431

ABSTRACT:
The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of anticancer agent to tumour cells. The inventive conjugate of said polypeptide contains doxorubicine and has a selective action on cancer tumours and can substantially reduce the resistance of tumour cells with respect to the anticancer agents, the conjugated parts of said agents being binded with the aid of a chemical bond which is unstable in relation to acid hydrolysis. The inventive pharmaceutical composition comprises an efficient quantity of conjugate and a carrier which is fit for intravenous injection. Said invention can be used for medicine for treating cancer patients.

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Lutsenko et al., “The Enhancement of Anticancer Activity of Doxorubicin by its Targeted Delivery to Cancer Cells via Protein Vectors”, Russian Oncological Journal, No. 3, pp. 33-37, 2001.

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