Polypeptide specifically inhibiting cathepsin L

Details Polypeptide specifically inhibiting cathepsin L Polypeptide specifically inhibiting cathepsin L

1995-06-07

1997-12-16

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, C07K 1400, C07K 710, C12N 1515

Patent

active

056985193

ABSTRACT:
The present invention provides a polypeptide having an amino acid sequence represented by Sequence No. 1 and a cathepsin L-specific inhibitor and therapeutic agent for osteoporosis comprising the polypeptide as its effective component. Since the polypeptide possesses potent inhibitory action specific to cathepsin L as well as strong bone resorption inhibitory action, the polypeptide is useful in the treatment of osteoporosis, particularly, senile osteoporosis.

REFERENCES:
Lenarck et al, FEBS Letters, vol. 336 (2) 27, Dec. 1993, pp. 289-292.
FEBS Letters, vol. 336, No. 2, pp. 289-292 (1993).
Biomed. Biochim Acta 45, pp. 1375-1384 (1986).
J. Biochem, vol. 105, No. 1, pp. 143-147 (1989).
V. Turk et al. "The cystatins: protein inhibitors of cysteine proteinases", FEBS Letters, vol. 285 No. 2, 22 Jul. 1991, Amsterdam NL, pp. 213-219.
B. Lenarcic et al, "Pig leukocyte cysteine proteinase inhidibor (PLCPI), a new member of the stefin family", FEBS Letters, vol. 336, No. 2, 27 Dec. 1993, Amsterdam NL, pp. 289-292.
A. Ritonja et al, "Primary structure of a new cysteine proteinase inhibitor from pig leucocytes" FEBS Letters, vol. 255, No. 2, 25 Sep. 1989, Amsterdam NL, pp. 221-214.

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