Polypeptide of protein P140 and DNAS encoding it

Details Polypeptide of protein P140 and DNAS encoding it Polypeptide of protein P140 and DNAS encoding it

1995-12-13

1998-09-08

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 536 235, C12P 2102, C12N 121, C12N 1563, C07H 2104

Patent

active

058044116

ABSTRACT:
The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improve the diabetes-derived hypoglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).

REFERENCES:
Fereydoun G. Sajjadi & Elena B. Pasquale "Five novel avian Eph-related tyrosine kinases are differentially . . . " Oncogene (1993), 8, 1807-1813.
Beatrix Bohme, Uwe Holtrich, George Wolf, Heike Luzius, Karl-Heinz Grzeschik, Klaus Strebhardt & Helga Rubsamen-Weigmann "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2" Oncogene (1993), 8, 2857-2862.
Stephanie Amiel "Amylin and diabetes" The Lancet (1993), 1249-1950.

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