Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA

Details Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA

1999-03-05

2000-03-14

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 435 72, 435183, 4352521, C12N 910

Patent

active

060371595

ABSTRACT:
Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below:

REFERENCES:
Yuichiro Yasumoto, et al., Characterization of a rat liver Golgi sulphotransferase responsible for the 6-O-sulphation of N-acetylglucosamine residues in .beta.-linkage to mannose: role in assembly of sialyl-galactosyl-N-acetylglucosamine 6-sulphate sequence of N-linked oligosaccharides, Biochem. J. (1996) 319,209-216.
Sophie Degroote, et al., Characterization of an N-Acetylglucosamine-6-O-sulfotransferase from Human Respiratory Mucosa Active on Mucin Carbohydrate Chains, The Journal of Biological Chemistry, vol. 272, No. 47, Issue of Nov. 21, pp. 29493-29501, 1997.
Kendra G. Bowman, et al., Identification of an N-acetylglucosamine-6-O-sulfotransferase activity specific to lymphoid tissue: an enzyme with a possible role in lymphocyte homing, Chemistry & Biology Aug. 1998, 5:447-460.
Kenji Uchimura, et al., Human N-Acetylglucosamine-6-O-Sulfotransferase Involved in the Biosynthesis of 6-Sulfo Sialyl Lewis X: Molecular Cloning, Chromosomal Mapping, and Expression in Various Organs and Tumor Cells, J. Biochem, 124, 670-678 (1998).
Kenji Uchimura, et al., Molecular Cloning and Characterization of an N-Acetylglucosamine-6-O-sulfotransferase, The Journal of Biological Chemistry, vol. 273, No. 35, Issue of Aug. 28, pp. 22577-22583, 1998.
Kiyoshi Nakazawa, et al., Glycosyltransferase and Sulfotransferase Activities in Chick Corneal Stromal Cells before and after in Vitro Culture, Archives of Biochemistry and Biophysics, vol. 359, No. 2, Nov. 14, pp. 269-282, 1998.

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