Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-07-17
2007-07-17
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S253100, C536S023100
Reexamination Certificate
active
09855604
ABSTRACT:
The invention concerns recombinant vectors replicated in mycobacteria, a set of sequences coding for exported polypeptides detected by fusion with alkaline phosphatase, in particular one polypeptide, called DP428, of about 12 kD corresponding to an exported protein found in mycobacteria belonging to theMycobacterium tuberculosiscomplex. The invention also concerns methods and kits for detecting in vitro the presence of amycobacteriumand in particular amycobacteriumbelonging to theMycobacterium tuberculosiscomplex in a biological sample using said polypeptides, their fragments or polynucleotides coding for the latter. The invention also concerns immunogenic or vaccine compositions for preventing and/or treating infections caused by mycobacteria and in particular amycobacteriumbelonging to said complex, particularly tuberculosis.
REFERENCES:
patent: 6248581 (2001-06-01), Gicquel et al.
patent: 2 767 336 (1999-02-01), None
patent: WO 9607745 (1996-03-01), None
De La Salmoniere Yves Goguet
Gicquel Brigitte
Guigueno Agnès
Lim Eng-Mong
Pelicic Vladimir
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Institut Pasteur
Katcheves Konstantina
Ketter James
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