Polypeptide, novel DNA and novel antibody

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S389100

Reexamination Certificate

active

07667005

ABSTRACT:
The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same.

REFERENCES:
patent: 5302706 (1994-04-01), Smith
patent: 5783680 (1998-07-01), Brunner et al.
patent: 5-506148 (1993-09-01), None
patent: 7-502651 (1995-03-01), None
patent: 91/15226 (1991-10-01), None
Nabeshima Y. Toward a better understanding of Klotho. Sci Aging Knowledge Environ. May 3, 2006;2006(8):pe11, 6 pages [online], [retrieved on Feb. 14, 2009]. Retrieved from the Internet:<URL:http://sageke.sciencemag.org/cgi/content/full/2006/8/pe11>.
Nature, vol. 390 (1997) 45-51.
Science, vol. 272 (1996) 258-62.
Science, vol. 269 (1995) 1236-41.
Nature, vol. 366 (1993) 701-04.
Experimental Cell Research, vol. 199 (1992) 355-62.
Database Accession No. H28389 XP-002213894, Hillier, et al., “y152e03.r1 Soares Breast 3NbHBstHomo sapiens. . . ” (1995).
Database Accession No. AAT27160 XP-002213952, Kakizuka, et al., “Human Machado-Joseph Disease Gene Probe” (1996).
Database Accession No. AAQ69624 XP-002213953, Andrews, et al., “Human bc1-2 proto-oncogene, target region”.
Database Accession No. R63458 XP-002214179, Hillier, et al., “yi08a10.r1 Soares placenta Nb2HPHomo sapiens. . . ” (1995).
Database Accession No. P09848 XP-002213895, Mantei, et al., “Lactase-phlorizin hydrolase precursor” (1989).
Database Accession No. AB005141 XP-002213896, Kuro-O, et al., “Mus musculus klotho mRNA, complete cds.” (1997).
Database Accession No. AB005142 XP-002213897, Kuro-O, et al., “Homosapients klotho mRNA, complete cds.” (1997).
Martin, et al., “Ageing: New mice for old Questions”, Nature, vol. 390 (1997) 18-19.
Bowie, et al., “Deciphering the message in protein sequences: tolerance to amino acid substitutions”, Science (1990), vol. 247 (4948) 1306-10.
Ngo, et al., “The Protein Folding Problem and Tertiary Structure . . . ”, Merz and Le Grand (Eds) (1994), Springer Verlag, 433 and 492-95.
Roush W., “Fast-forward aging in a mutant mouse?”, Science (1997), vol. 278 (5340) 1013.
Henikoff et al., “Gene Families: the taxonomy of protein paralogs and chimeras”, Science (1997), vol. 278 (5338) 609-14.
Wu et al., “Naturalization of heparin activity by neutrophil lactoferrin”, Blood (1995), vol. 85 (2) 421-8.
Tomasetto et al., “hSP, the domain-duplicated homolog of pS2 protein, . . . ” EMBO J, vol. 9 (2) (1990) 407-14.
Playford et al., “Human Spasmolytic Polypeptide is a cytoprotective agent that stimulates cell migration”, Gastroenterology, vol. 108, No. 1 (1995) 108-16.
Mian IS, “Sequence, Structural, Functional, and Phylogenetic Analyses of . . . ”, Blood Cells Mol. Dis., vol. 24, No. 1 (1998) 83-100.
Sambrook, et al., “Molecular Cloning: A Laboratory”, Cold Spring Harbor Lab. Press (1989) 9.50.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polypeptide, novel DNA and novel antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptide, novel DNA and novel antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide, novel DNA and novel antibody will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4231186

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.