Polypeptide monomers, linearly extended and/or crosslinked forms

Details Polypeptide monomers, linearly extended and/or crosslinked forms Polypeptide monomers, linearly extended and/or crosslinked forms

1992-02-19

1996-11-12

Seidleck, James J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530331, A61K 3804

Patent

active

055741347

ABSTRACT:
A water-resistant polyphenolic protein adhesive has been obtained from the Atlantic ribbed mussel, Geukensia (Modiolus) demissa. This protein provides a natural model for synthetic or bioengineered adhesives and is characterized by a Gly-Tyr-Lys or, more frequently, Gly-Dop-Lys "tail" fragment of a repeating octapeptide or nonapeptide unit. A complete octapeptide or nonapeptide unit (including both the 5- or 6-amino acid residue "head" as well as the 3-residue "tail") can be represented as follows:

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