Polypeptide mediating cell permeability

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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Details

C530S350000

Reexamination Certificate

active

09830981

ABSTRACT:
The present invention relates to a cell-permeable polypeptide that can mediate cell permeability to substances, DNA coding for said polypeptide and a method for the production of said polypeptide. The invention also relates to antibodies directed against the polypeptide and the use of said polypeptide in the mediation of cell permeability to substances.

REFERENCES:
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NCBI Accession # 540642.
NCBI Accession # 138800.
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Wieprecht T. et al, “Influence of the angle subtended by the positively charged helix face on the membrane activity of amphipathic, antibacterial peptides”, BIOCHEMISTRY, Bd. 36, 1997, Seiten 12869-12880, XP002141072 Zusammenfassung.
Oess S. et al, “Novel cell permeable motif derived from the PreS2-domain of hepatitis-B virus surface antigens” Gene Therapy, Bd. 7, Nr. 9, May 2000, Seiten 750-758, XP000922825.
Lehninger, Alfred L., “Principles of Biochemistry”, Second Edition, Worth Publishers, New York, NY (1993), p. 113.
Oess et al., “Novel cell permeable motif derived from the PreS2-domain of hepatitis B virus surface antigens” Gene Therapy, vol. 7, pp. 750-758 (2000).

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