Polypeptide inhibiting a proton-gated Na+ channel, a nucleic...

Details Polypeptide inhibiting a proton-gated Na+ channel, a nucleic... Polypeptide inhibiting a proton-gated Na+ channel, a nucleic...

2006-11-07

2006-11-07

Pak, Michael (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C530S300000, C530S344000, C514S002600, C514S021800

Reexamination Certificate

active

07132505

ABSTRACT:
The invention relates to a substantially pure polypeptide functioning as an ASIC1a channel blocker. Also provided is a nucleic acid molecule coding such polypeptide, pharmaceutical composition containing such polypeptide and a method of manufacturing an ASIC1a channel blocker.

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Chen, C.C., England, S., Akopian, A.N and Wood, J.N., “a Sensory Neuron-Specific, Proton-Gated Ion Channel” , Proc. Natl. Acad. Sci. USA, 95, 10240-10245, 1998.
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Waldmann, R., Bassilana, F., de Weille, J., Champigny, G., Heurteaux, C. and Lazdunski, M., “Molecular Cloning of a Non-Inactivating Proton-Gated Na+ Channel Specific for Sensory Neurons”, J. Biol. Chem., 272, 20975-209758, 1997.
Hucho, F. (1995), “Toxins as tools in neurochemistry”, Ang. Chem. Int. Ed. Eng., 34, 39-50.
Narasimhan, L., Singh, Jr., Humblet, C. Guruprasad, K. and Blundell, T., “Snail and Spider Toxins Share a Similar Tertiary Structure and ‘Cystine Motif’”, Nat. Struct. Biol., 1, 850-852, 1994.
Pallaghy, P.K., Nielsen, K.J., Cralk, D.J. and Norton, R.S., “A Common Structural Motif Incorporating a Cystine Knot and a Triple-stranded Beta-sheet in Toxic and Inhibitory Polypeptides”, Protein Sci., 3, 1833-1839, 1994).
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