Polypeptide-induced monoclonal receptors to protein ligands

Details Polypeptide-induced monoclonal receptors to protein ligands Polypeptide-induced monoclonal receptors to protein ligands

1994-09-02

1998-07-28

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 702, 435 7021, 43524027, 4351723, 436518, 5303877, 5303888, 5303897, 935 15, C12P 2104

Patent

active

057861781

ABSTRACT:
Monoclonal receptors raised to immunogenic polypeptides whose amino acid residue sequences correspond to sequences of oncoprotein ligands are disclosed, as are method for the production of those receptors and products and methods that utilize them. The monoclonal receptors bind both to the oncoprotein ligand to a portion of which the polypeptide corresponds in sequence, and to the immunogenic polypeptide to which the receptors were raised.

REFERENCES:
Lerner, Nature 299: 592-596 (1986) Tapping the Immunological Repetoire to Produce Antibodies.
Niman et al, PNAS 80:4949-4953 (1983) Generation of Protein-Reactive Antibodies by Short.

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