Polypeptide having Factor Xa inhibitory activity

Details Polypeptide having Factor Xa inhibitory activity Polypeptide having Factor Xa inhibitory activity

1997-01-07

1999-01-12

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530324, 530350, 530395, 530858, 435226, A61K 3855, A61K 3858, C07K 1481, C07K 14815

Patent

active

058589708

ABSTRACT:
A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.

REFERENCES:
patent: 4588587 (1986-05-01), Gasic
patent: 4742004 (1988-05-01), Hartman et al.
patent: 4791100 (1988-12-01), Kramer et al.
patent: 4832849 (1989-05-01), Cardin
patent: 5114922 (1992-05-01), Maschler
patent: 5182113 (1993-01-01), Rigbi
patent: 5403596 (1995-04-01), Rigbi
Baskova et al., Chemical Abstracts, 106:60996w (1986).
Condra et al., "Isolation and Structural Characterization of a Potent Inhibitor of Coagulation Factor Xa from the Leech Haementeria ghilianii", Thrombosis and Homeostasis 61(3): 437-441 (1989).
Methodologies for Protein Disposition Studies, Protein Pharmacokinetics and Metabolism; Plenum Press. New York, 1992. pp. 1-33.
Han et al., (1989) "Cloning and Expression of cDNA Encoding Antistasin, a Leech-Derived Protein Having Anti-Coagulant and Anti-Metastatic Properties", Gene 75:47-57.
Gasic et al., Cancer Res. 44:1633-1636 (1983).
Gasic et al., Cancer Res. 44:5670-5676 (1984).
Gasic et al., Chemical Abstracts 110:185955w (1986).
Hoffman et al., (1992) "Site-Directed Mutagenesis of the Leech-Derived Factor Xa Inhibitor Antistasin", Journ. Biol. Chem., 287:943-949.
Hopp et al., (1988) "A Short Polypeptide Marker Sequence Useful For Recombinant Protein Identification And Purification", Bio/technology 6:1204-1210.
Konrad, Michael W., (1993) "The Immune System as a Barrier to Delivery of Protein Therapeutics", Biological Barriers to Protein Delivery Plenum Press, New York. pp. 409-437.
Nutt et al., (1988) "The Amino Acid Sequence of Antistasin", Journ. Biol. Chem. 263(11): 10162-10164.
Rigbi et al., (1990) Chemical Abstracts, 113:46259W.
Tuszynski et al., (1987) "Isolation and Characterization of Antistasin", 262(20): 9718-9723.
Dunwiddie et al. (1989), J.Biol. Chem. 264(28): 16694-16699.
Sollner et al., Eur. J. Biochem. 219: 937-943 (1994).

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