Polypeptide having c-AMP-producing activity

Details Polypeptide having c-AMP-producing activity Polypeptide having c-AMP-producing activity

1991-07-18

1993-05-04

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, A61K 3702, C07K 710

Patent

active

052083209

ABSTRACT:
A polypeptide or a pharmaceutically acceptable salt thereof having c-AMP-producing activity is disclosed, the polypeptide being represented by the following general formula:

REFERENCES:
Ogi et al., Biochemical and Biophysical Research Communications, vol. 173, No. 3, 1990.
Nilsson, vol. 60, No. 2, FEBS Letter, Dec. 1975.
Kimura et al., Biochemical and Biophysical Research Communications vol. 166, No.1 , 1990.
Miyata, et al., Biochemical and Biophysical Research Communications, vol. 164, No. 1, 1989.
Miyata, et al., "Isolation and Characterization of a Novel Ovine Hyopthalamic Polypeptide Which Stimulates Adenylate Cylase in Rat Pituitary Cell Cultures", Proceedings of the 19th Annual Meeting of the Society for Neuroscience, 1989, p. 1277.
A. Miyata, et al., Biochem, Biophys. Res. Commun., 164:567-574 (1989).
C. Kimura, et al. Biochem. Biophys. Res. Commun., 166:81-89 (1990).
K. Koves, et al., Endocrinology, 127:264-271 (1990).

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