Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1994-11-07
1996-06-18
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
530313, 530329, A61K 3800, C07K 700, C07K 706, C07K 718
Patent
active
055278825
ABSTRACT:
The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise:
a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.
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Mitchell Alexander R.
Young Janis D.
Marshall S. G.
The Regents of the University of California
Warden Jill
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