Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Reexamination Certificate
2003-04-25
2008-10-21
Bunner, Bridget E (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
C530S350000, C536S023500
Reexamination Certificate
active
07439332
ABSTRACT:
A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
REFERENCES:
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 2003/0022217 (2003-01-01), Ceccardi et al.
patent: 0 953 354 (1999-11-01), None
patent: WO 99 03980 (1999-01-01), None
patent: WO 02 060942 (2002-08-01), None
patent: WO 02 070539 (2002-09-01), None
patent: WO 02 100898 (2002-12-01), None
Kapur et al. The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel17H mice. Blood 94(6): 1915-1925, 1999.
Sher et al. Mutations uncouple human fibroblast growth factor (FGF)-7 biological activity and receptor binding and support broad specificity in the secondary receptor binding site of FGFs. J Biol Chem 274(49): 35016-35022, 1999.
Wuyts et al. NH2- and COOH-terminal truncations of murine granulocyte chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic potency. J Immunol 163: 6155-6163, 1999.
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech 18(1): 34-39, 2000.
Bork, A. Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res 10: 398-400, 2000.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223, 1997.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4): 132-133, 1999.
Bork et al. Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10): 425-427, 1996.
Wells, J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Wognum et al. Identification and isolation of hematopoietic stem cells. Arch Med Res 34: 461-475, 2003.
Quesenberry et al. “Hematopoietic stem cells, progenitor cells, and cytokines”, pp. 153-174, Williams Hematology, Sixth Edition, New York: McGraw-Hill, 2001.
Database WPI, Section Ch, Week 199911 Derwent Publications, AN 1999-13227, Abstract for WO 9903980, Database Accession No. 1999-132227, Jan. 28, 1999 (XP002248950), 2 pages.
Database EMBL ′Online!, the sequences from Adachi, J. et al., “Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library clone:C630007L04 product:hypothetical Thrombospondin type 1 repeat (TSP1) profile/Thrombospondin type I domain/Furin-like cystein rich region containing protein, full insert sequence,” Database Accession No. AK049891, (XP002248970), 3 pages, Mar. 1, 2003.
Database EMBL ′Online!, the sequences from Strausberg, R.L. et al., “Homo sapiens hypothetical protein MGC35555, mRNA (cDNA clone MGC:35555 Image:5201681), complete cds,” Database Accession No. BC027938, (XP002248948), 3 pages, May 15, 2003.
Database GenSeq ′Online!, the sequences from Tang, Y.T. et al., “Human polypeptide Seq ID No. 1165,” Database Accession No. ABP69118, Jan. 20, 2003 (XP002248949), 1 page.
Drmanac, S. et al., “Accurate sequencing by hybridization for DNA diagnostics and individual genomics,” Nature Biotechnology, vol. 16, Jan. 1998 (XP001064848), pp. 54-58.
Moore, K.A. et al., “Hermatopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs,” Proc. Natl. Acad. Sci. USA, vol. 94, Apr. 1997 (XP002943669), pp. 4011-4016.
Moore, K.A. et al., “In Vitro Maintainance of Highly Purified, Transplatable Hematopoietic Stem Cells,” Blood, vol. 98, No. 12, Jun. 15, 1997 (XP002220989), pp. 4337-4347.
Xu, M. et al. “Stimulation of Human Primitive Hematopoiesis by Murine AGM-Derived Stromal Cells,” Blood, vol. 90, No. 10, Nov. 15, 1997 (XP002911189), p. 483A.
Bent Stephen A.
Bunner Bridget E
Foley & Lardner LLP
Kirin Pharma Kabushiki Kaisha
McCaslin Richard B.
LandOfFree
Polypeptide having an activity to support proliferation or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polypeptide having an activity to support proliferation or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide having an activity to support proliferation or... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3992453