Polypeptide having affinity for lipopolysaccharide and method fo

Details Polypeptide having affinity for lipopolysaccharide and method fo Polypeptide having affinity for lipopolysaccharide and method fo

1992-08-07

1995-05-16

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Separation or purification

530317, 530326, 530344, 530333, A61K 3702, A61K 3720, C07K 512, C07K 708

Patent

active

054161940

ABSTRACT:
This invention relates to a novel polypeptide represented by the formula: ##STR1## wherein Lys represents lysine, Trp tryptophan, Cys cystine, Phe phenylalanine, Arg arginine, Val valine, Tyr tyrosine, Gly glycine, Ile isoleucine and X a hydroxyl group or an amino group), its analogue and a method for preparing the same.
The polypeptide exhibits strong affinity for lipopolysaccharide, and is useful for removing endotoxin and as a therapeutic agent of bacterial infections, and a method for preparing the same.

REFERENCES:
patent: 5068314 (1991-11-01), Nakamura et al.
Morita, et al., J. Biochem., 97, 1611-1620 (1985).
Annex I--J. Biochem., 97, 1611-1620 (1985).
Annex II--vol. 261, No. 16, pp. 7357-7365, Jun. 5 issue.
Annex III--Eur. J. Biochem., 154, 511-521 (1986).
Annex IV--vol. 263, No. 32, Nov. 15 issue, pp. 16709-16713.
Annex V--vol. 252, No. 1, 2, 121-124, Jul. 1989.

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