Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Reexamination Certificate
2007-03-20
2007-03-20
Wang, Andrew (Department: 1639)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
C530S300000
Reexamination Certificate
active
10772537
ABSTRACT:
This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an apoptosis-inducing activity. Specifically, the amino acid sequence of this peptide is His Thr Phe Ser Gly Val Ala Ser Val Glu and correlates to amino acid no. 300-309 of fetuin, referred to herein as Fetuin Peptide Fragment (FPF 300-09). FPF 300-09 strongly induced apoptosis in LNCaP (prostate cancer) and HT-29 (colon cancer) cells without affecting CCD 18 Co (normal colon) cells. The in vitro tissue culture study demonstrated that the FPF 300-09 is more potent than the parent molecule (full-length zinc charged fetuin) in inducing apoptosis. FPF 300-09 has a LD50of 0.3–0.4 μM while the LD50for zinc-charged fetuin is 3–10 μM.
REFERENCES:
Brown et al., Eur. J. Biochem. vol. 205 pp. 321-331 (1992).
Rudinger, Peptide Hormones, (Jun. 1976) (J.A. Parsons, editor) 1-6.
Steele Amber D
Trojan Law Offices
Wang Andrew
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