Polypeptide for obesity and type II diabetes mellitus

Details Polypeptide for obesity and type II diabetes mellitus Polypeptide for obesity and type II diabetes mellitus

1998-06-15

1999-03-02

Myers, Carla J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 530827, 536 235, C07K 14435

Patent

active

058772839

ABSTRACT:
The present invention provides a novel polypeptide characterized by a non-conservative missense mutation, Trp64Arg, in the .beta.3-adrenergic receptor (.beta.3AR) that increases susceptibility to obesity and non-insulin dependent diabetes mellitus (NIDDM; type II diabetes). Also provided are methods of diagnosis and methods of treatment of subjects having or at risk of having type II diabetes/obesity.

REFERENCES:
patent: 5288607 (1994-02-01), Emorine et al.
Lelias et al., Molecular cloning of a human .beta.3-adrenergic receptor cDNA, Febs Letters, 324(2) :127, 1993.

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