Polypeptide films and methods

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07973129

ABSTRACT:
Disclosed herein are polypeptide multilayer films wherein a therapeutic agent is covalently linked to a first layer polypeptide. An advantage of such attachment is that the linked therapeutic agent can be controllably released from the multilayer film into the environment of the film upon the addition of a suitable stimulus. An advantage of the disclosed films and methods is enablement of environmentally-stimulated release under specific conditions.

REFERENCES:
patent: 6020175 (2000-02-01), Onda et al.
patent: 6479146 (2002-11-01), Caruso et al.
patent: 7550557 (2009-06-01), Haynie
patent: 7662911 (2010-02-01), Haynie et al.
patent: 7759305 (2010-07-01), Haynie
patent: 2004/0013721 (2004-01-01), Antipov et al.
patent: 2005/0069950 (2005-03-01), Haynie
patent: 2005/0180945 (2005-08-01), Chaikof et al.
patent: 2007/0207212 (2007-09-01), Haynie et al.
patent: WO 2008013558 (2008-01-01), None
Chluba et al. “Peptide Hormone Covalently Bound to Polyelectrolytes and Embedded into Multilayer Architectures Conserving Full Biological Activity,” Biomacromolecules, 2001, 2, 800-805.
Thierry et al. “Delivery Platform for Hydrophobic Drugs: Prodrug Approach Combined with Self-Assembled Multilayers,” J. Am. Chem. Soc., 2005, 127, 1626-1627.
Li et al. “Complete Regression of Well-established Tumors Using a Novel Water-soluble Poly(L-Glutamic Acid)-Paclitaxel Conjugate,” Cancer Research, 1998, 58, 2404-2409.
Vodouhe et al. “Control of drug accessibility on functional polyelectrolyte multilayer films,” Biomaterials, 2006, 27, 4149-4156.
Thierry et al. “Bioactive Coatings of Endovascular Stents Based on Polyelectrolyte Multilayers,” Biomacromolecules, 2003, 4, 1564-71.
Etienne et al. “Antifungal coating by biofunctionalized polyelectrolyte multilayered films,” Biomaterials, 2005, 26, 6704-6712.
Etienne et al. “Multilayer Polyelectrolyte Films Functionalized by Insertion of Defensin: a New Approach to Protection of Implants from Bacterial Colonization,” Antimicrobial Agents and Chemotherapy, 2004, 48, 3662-3669.
International Search Report and Written Opinion; International Application No. PCT/US2008/000805; International Filing Date Jan. 22, 2008; Date of Mailing Jul. 11, 2008; 13 pages.
Haynie, et al.; “Protein-Inspired Multilayer Nanofilms: Science, Technology and Medicine”; Nanomedicine: Nanotechnology, Biology, and Medicine; 2; pp. 150-157; (2006).
Zheng, et al.; “Design of Peptides for Thin Films, Coatings and Microcapsules for Applictions in Biotechnology”; J. Biomater: Sci. Polymer Edn.; 16; pp. 285-299; (2005).
Haynie, et al.; “Polypeptide Multilayer Films: Role of Molecular Structure and Charge”; Langmuir; 20; pp. 4540-4547; (2004).
Schultz et al.; “Polyelectrolyte Multilayers Functionalized by a Synthetic Analogue of an Anti-Inflammatory Peptide, a-MSH, for Coating a Trachael Prosthesis”; Biomaterials; 26; pp. 2621-2630; (2005).
Shneider et al., “Multifunctional Polyelectrolyte Multilayer Films: Combining Mechanical Resistance, Biodegradability, and Bioactivity”; Biomacromolecules; 8; pp. 139-145; (2007).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polypeptide films and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptide films and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide films and methods will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2696786

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.