Polypeptide ESDN, polynucleotides encoding the polypeptide,...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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Reexamination Certificate

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06900031

ABSTRACT:
The invention discloses a useful and novel factor (polypeptide) which plays an important role for morbid vascular smooth muscle in restenosis after percutaneous transluminal coronany angioplasty (PTCA) and arterial sclerosis in the field of cardiovascular system.

REFERENCES:
patent: 5536637 (1996-07-01), Jacobs
patent: 2003/0032154 (2003-02-01), Gu et al.
patent: WO 00/12532 (2000-03-01), None
Kobuke et al. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. J. Biol. Chem. (Sep. 7, 2001) 276: 34105-34114.*
Sequence Report. TrEMBLrel. 19, created Dec. 1, 2001. Result 1.*
Manning et al. Stability of Protein Pharmaceuticals. Pharmaceutical Research (1989) 6: 903-918.*
Benet et al. Pharmacokinetics: The dynamics of Drug Absorption, Distribution, adn Elimination. McGraw-Hill (1990): 3-32.*
Kazuhiro Kobuke, et al, “ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury,” The Journal of Biological Chemistry Website, Jul. 10, 2001.

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