Polypeptide, DNA fragment encoding the same, drug composition co

Details Polypeptide, DNA fragment encoding the same, drug composition co Polypeptide, DNA fragment encoding the same, drug composition co

1992-11-05

1995-09-19

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

435 691, 435 692, 435212, 435213, 435218, 4352523, 4353201, 530300, A61K 3800, C12P 2106, C12N 120, C12N 948

Patent

active

054516595

ABSTRACT:
This invention particularly provides a novel polypeptide having high protease-inhibiting activity, preferably FXa-inhibiting activity, which comprises, at least as a part of the polypeptide, an amino acid sequence resulting from substitution of an amino acid for at least one amino acid in the following amino acid sequence (1), wherein the amino acid substitution is at least one substitution selected from the following substitution means (i) to (iii). It also provides a process for the production of the polypeptide, a novel DNA fragment encoding the polypeptide and a drug composition containing the same.

REFERENCES:
Laskowski, Jr., Biochemical Pharmacology, vol. 29, pp. 2089-2094 (1980).
Brinkmann et al, Eur. J. Biochem., vol. 202, pp. 95-99 (1991).
Wachter et al, Hoppe-Seyler's Z. Physiol. Chem. Bd. 360, S. 1297-1303 (1979).
Jean-Philippe Salier, TIBS 15, pp. 435-439 (1990).
Ohnishi et al, Folia pharmacol. japon, vol. 85, pp. 1-6 (1985).
Sakuragawa et al, Chemical Abstracts, vol. 107:228724c, 1987.
Traboni et al. "Sequence of a Full Length DNA . . . " NAR 14:15 p. 6340 1986.
Kaumeyer et al. "The mRNA for a proteinase . . . " NAR 14:20 pp. 7839-7850.

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