Polypeptide, DNA fragment encoding the same, drug composition co

Details Polypeptide, DNA fragment encoding the same, drug composition co Polypeptide, DNA fragment encoding the same, drug composition co

1995-04-28

1996-12-31

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 692, 4351723, 4352523, 4352402, 435212, 435213, 435218, 4353201, 530300, 530324, 536 221, 536 231, 536 235, C12P 2106, C12N 120, C07H 1900, C07H 2100

Patent

active

055893600

ABSTRACT:
This invention particularly provides a novel polypeptide having high protease-inhibiting activity, preferably FXa-inhibiting activity, which comprises, an lease as a part of the polypeptide, an amino acid sequence resulting from substitution of an amino acid for at least one amino acid in the following amino acid sequence (1), wherein the amino acid substitution is at least one substitution selected from the following substitution means (i) to (iii). It also provides a process for the production of the polypeptide, a novel DNA fragment encoding the polypeptide and a drug composition containing the same.

REFERENCES:
Jean-Philippe Salier, TIBS 15:435-439 (1990).
Ohnishi et al., Folia pharmacol. japon, vol. 85, pp. 1-6 (1985).
Laskowski, Jr., Biochemical Pharmacology, vol. 29, pp. 2089-2094 (1980).
Brinkmann et al. Eur. J. Biochem., vol. 202, pp. 95-99 (1981).
Wachter et al., Hoppe-Seyler's Z. Physiol. Chem. Bd. 360:1297-1303 (1979).
Traboni et al. "Sequence of a full length cDNA . . . ", NAR 14(15):6340 (1986).
Kaumeyer et al. "The mRNA for a proteins . . . ", NAR 14(20):7839-7850 (1986?).
Sakuragawa et al., Chem. Abstr. 107:228724c (1987).

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