Polypeptide, DNA fragment encoding the same, drug composition co

Details Polypeptide, DNA fragment encoding the same, drug composition co Polypeptide, DNA fragment encoding the same, drug composition co

1993-05-06

1997-10-21

Jacobson, Dian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 435 692, 435212, 435213, 435218, A61K 3816, A61K 3855, C07K 1400, C07K 1481

Patent

active

056797702

ABSTRACT:
This invention particularly provides a novel polypeptide having high protease-inhibiting activity, preferably FXa-inhibiting activity, which comprises, at least as a part of the polypeptide, an amino acid sequence resulting from substitution of an amino acid for at least one amino acid in the following amino acid sequence (1), wherein the amino acid substitution is at least one substitution selected from the following substitution means (i) to (iii). It also provides a process for the production of the polypeptide, a novel DNA fragment encoding the polypeptide and a drug composition containing the same.
Amino acid sequence (1) ##STR1## (i) Substitution of 15 position Gln counting from the N-terminus by an amino acid other than Gln.

REFERENCES:
Kaumeyer et al. "The mRNA for a proteinas etc." Nuclear Acid Research vol. 14, No. 20 (1986) p. 7839.
Trabomi et al. "Sequen of a full length etc." Nuclear Acid Research vol. 14, No. 15 (1986) p. 6340.
Laskowski "An algorithmic approach . . ." Biochemical Pharmocology vol. 29 pp. 2089-2094 (1980).

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