Polypeptide derived from a popamine receptor, and compositions a

Details Polypeptide derived from a popamine receptor, and compositions a Polypeptide derived from a popamine receptor, and compositions a

1993-09-09

1996-04-16

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C07K 14705

Patent

active

055083846

ABSTRACT:
Compounds, compositions and methods involving purified, isolated and/or synthetic G-protein coupled receptor (GPR) polypeptides that comprise fragments, derivatives and/or consensus peptides of transmembrane domains of G-coupled receptor proteins, wherein the GPR polypeptide has biological activity selected from binding of a GPR ligand to a GPR or modulating the binding of a GPR ligand to a GPR.

REFERENCES:
FASEB, J. 3:1825-1832, May 1984, Strader et al. Structural Basis of .beta.-adrenergic receptor function.
Pharmac. Ther. 50:425-442, 1991, Jackson Structure and Function of G Protein Coupled Receptors.
Science 246:1310-1316, 03 Jun., 1988, Kobilka et al. Chimeric .alpha..sub.2,.beta..sub.2 -Adrenergic Receptors: Delineation of Domains Involved in Effects-Coupling and Ligand Binding.
Nature 336:783-787, 22 Dec. 1988, Bunzow et al, Cloning and Expression of a rat D.sub.2 dopamine receptor cDNA.

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