Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1992-12-22
1994-11-08
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530395, 530820, 530825, 930145, 424 851, C07K 1300
Patent
active
053628535
ABSTRACT:
Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
REFERENCES:
patent: 4810643 (1989-03-01), Souza
patent: 4904584 (1990-02-01), Shaw
Wills et al, Gene, 34, 1985, pp. 315-323.
Zoller et al, Nucleii Acid Ris 10(20) 1982, pp. 6487-6500.
Itoh Seiga
Komatsu Yoshinori
Kuga Tetsuro
Miyaji Hiromasa
Morimoto Makoto
Draper Garnette D.
Kyowa Hakko Kogyo Co. Ltd.
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