Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-05-03
1998-02-03
Fitzgerald, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 435 695, 435 691, C07K 14535, C07K 1400
Patent
active
057145814
ABSTRACT:
Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
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Ayala et al. 1980, Modern Genetics, Benjamin/Cummings Publishing Co., Menlo Park, CA, pp. 45-48.
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Itoh Seiga
Komatsu Yoshinori
Kuga Tetsuro
Miyaji Hiromasa
Morimoto Makoto
Fitzgerald David L.
Kemmerer Elizabeth C.
Kyowa Hakko Kogyo Co. Ltd.
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