Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1991-04-29
1995-05-16
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530395, 930145, 424 851, C07K 1300
Patent
active
054161959
ABSTRACT:
Derivatives of naturally occurring G-CSF having at least one of the biological properties of naturally occurring G-CSF, and a solution stability of at least 35% at 5 mg/ml are disclosed in which the derivative has at least Cys.sup.17 of the native sequence replaced by a Ser.sup.17 residue and Asp.sup.27 of the native sequence replaced by a Ser.sup.17 residue. Nucleotide sequences coding for part or all of the amino acid sequence of the derivatives of the invention may be incorporated into autonomously replicating plasmid or viral vectors employed to transform or transfect suitable procaryotic or eucaryotic host cells such as bacteria, yeast or vertebrate cells in culture.
REFERENCES:
patent: 4810643 (1989-03-01), Souza
patent: 5104651 (1992-04-01), Boone et al.
patent: 5214132 (1993-05-01), Kuga et al.
patent: 5218092 (1993-06-01), Sasaki
Wingfield et al, Biochem J 256(1) 1988, pp. 213-218 (abst only).
Clark-Lewis et al, Structure-Function Studies of Human Granulocyte-Macrophage Colony-Stimulating Factor, The Journal of Immunology, vol. 141, 881-889, Aug. 1, 1988.
Camble Roger
Carr Heather
Timms David
Wilkinson Anthony J.
Carlson K. Cochrane
Draper Garnette D.
Zeneca Limited
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