Polypeptide derivatives

Details Polypeptide derivatives Polypeptide derivatives

1989-02-23

1992-11-10

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530307, A61K 3702

Patent

active

051623056

ABSTRACT:
Novel synthetic polypeptide derivatives, i.e., novel calcitonin derivatives, having improved basic physiological activities of the corresponding natural calcitonins, i.e., the activity for lowering the blood level of calcium, the activity as an analgesic, as well as the activity for inhibiting the secretion of the gastric juice. Thus these synthetic calcitonins are effective as agents for curing hypercalcemia, analgetic agents, anti-ulcerative agents and the like.

REFERENCES:
patent: 4086221 (1978-04-01), Sakakibara et al.
patent: 4277393 (1981-07-01), Sakakibara et al.
patent: 4639511 (1987-01-01), Orlowski et al.
patent: 4663309 (1987-05-01), Kaiser et al.
patent: 4703106 (1987-10-01), Hirone et al.
patent: 4743677 (1988-05-01), Noda et al.
Findlay, D. M., et al., "Biological Activities and Receptor Interactions of des-Leu-16 Salmon and des-Phe-16 Human Calcitonin," Endocrinology, vol. 112, No. 4, pp. 1288-1291, 1989.
Current Therapeutic Research 45:502-515 (1989).
Morikawa et al., Experientia 32:1104-1106 (1976).

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