Polypeptide derivatives

Details Polypeptide derivatives Polypeptide derivatives

1977-09-23

1979-09-18

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3702

Patent

active

041682637

ABSTRACT:
There is presented peptide derivatives comprising polypeptides to which are bound via its functional side-chains penicilloyl residues of the formula ##STR1## wherein R signifies 2-pentenyl, n-pentyl, n-heptyl, allylthiomethyl, 5-amino-5-carboxypentyl, benzyl, .alpha.-carboxy benzyl, .alpha.-aminobenzyl, phenoxy benzyl, phenoxymethyl, .alpha.-phenoxy ethyl, .alpha.-phenoxypropyl, 2,6-dimethoxyphenyl, 2-ethoxy-1-naphthyl, 3-carboxy-2-quinoxazinyl, 5-methyl-3-phenyl-4-isoxazolyl, .alpha.-amino-p-hydroxy benzyl, 3-(2-chlorophenyl)-5-methyl-4-isoxazolyl, 3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl, 3-(2-chloro-6-fluoro-phenyl)-5-methyl-4-isoxazolyl, .alpha.-carboxy-3-thienylmethyl or .alpha.-sulphonylbenzyl.
The peptide derivatives exhibit antiallergic activity.

REFERENCES:
patent: 2625543 (1953-01-01), Ruskin
patent: 3592804 (1971-07-01), Quitt et al.
patent: 3867365 (1975-02-01), Stahmann et al.
Schneider, et al., Helv. Chim. Acta, 49, 1966, pp. 1695-1705.
N. Chiorazzi, et al., Proc. Natl. Acad. Sci. USA, 73, 1976, pp. 2091-2095.
Schneider, et al., Nature, 1965, pp. 57-59.

Affiliated with

Also associated with

Rating

Polypeptide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-897239