Polypeptide conjugates with extended circulating half-lives

Details Polypeptide conjugates with extended circulating half-lives Polypeptide conjugates with extended circulating half-lives

2007-03-06

2007-03-06

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

C435S188000, C514S007600, C530S345000, C530S351000, C530S352000, C530S409000, C530S410000, C544S214000, C544S232000

Reexamination Certificate

active

10487025

ABSTRACT:
The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit high affinity for human serum albumin.

REFERENCES:
patent: 5233023 (1993-08-01), Balkovec et al.
patent: 5677450 (1997-10-01), Suzuki et al.
patent: 5863905 (1999-01-01), Suhadolnik et al.
patent: 5962437 (1999-10-01), Kucera et al.
patent: 63-275661 (1988-11-01), None
US 5,739,275, 04/1998, Pang et al. (withdrawn)
Zobel et al., “Phosphate Ester Serum Albumin Affinity Tags Greatly Improve Peptide Half-Life In Vivo,”Bioorganic & Medicinal Chemistry Letters, 2003, 13:1513-1515.

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