Polypeptide comprising repeated cell-adhesive core sequences

Details Polypeptide comprising repeated cell-adhesive core sequences Polypeptide comprising repeated cell-adhesive core sequences

1992-07-13

1993-08-17

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 530324, 530325, 530326, 530327, 530328, 930DIG800, C07K 706, C07K 708, C07K 710, A61K 3702

Patent

active

052369030

ABSTRACT:
A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:

REFERENCES:
patent: 4929601 (1990-05-01), Brunetto et al.
patent: 4988621 (1991-01-01), Ruoslahti et al.
patent: 5041380 (1991-08-01), Ruoslahti et al.
Humphries et al, Science, vol. 23, Jul. 25, 1986, pp. 467-470, "A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells".
Iwamoto et al, Science, vol. 238, Nov. 20, 1987, pp. 1132-1134, "YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation".
Saiki et al, British Journal of Cancer, vol. 59, No. 2, Feb. 1989, pp. 194-197, "The Inhibition of Murine Lung Metastasis by Synthetic Polypeptides . . . ".
EMBO Journal, vol. 4, 1985, pp. 2519-2524, IRL Press Ltd., Oxford, Great Britain, S. Suzuki et al, "Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitro-nectin and fibronectin".
Partial European Search Report of EP 89 11 1468, Nov. 26, 1990.
Kunitake et al., Adv. Polymer Sci., 20: 159-211, 1976.
Nishi et al., Int. J. Peptide Protein Res., 30: 275-283, 1987.
Saiki, I. et al., Cancer Research, 49, 3815-3822, Jul. 15, 1989.
Ruoslahti et al. Science 238 491 (1987) [Oct. 23].
Tressler et al. Cancer Communications 01 (1989) 55-63.

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