Polypeptide comprising repeated cell-adhesive core sequences

Details Polypeptide comprising repeated cell-adhesive core sequences Polypeptide comprising repeated cell-adhesive core sequences

1989-06-23

1993-02-02

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 17, 530324, 530325, 530326, 530327, 530328, 530329, 930DIG8, C07K 706, C07K 708, C07K 710, A61K 3702

Patent

active

051838044

ABSTRACT:
A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:

REFERENCES:
patent: 4929601 (1990-05-01), Brunett et al.
patent: 4988621 (1991-01-01), Ruoslahti et al.
Kunitake et al., Adv. Polymer Sci., 20: 159-211, 1976.
Nishi et al., Int. J. Peptide Protein Res., 30: 275-283, 1987.
Saiki, I. et al., Cancer Research, 49, 3815-3822, Jul. 15, 1989.
EMBO Journal, vol. 4, 1985, pp. 2519-2524, IRL Press Ltd., Oxford, Great Britain, S. Suzuki et al, "Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitro-nectin and fibronectin".
Partial European Search Report of EP 89 11 1468, Nov. 26, 1990.
Humphries et al, Science, vol. 23, Jul. 25, 1986, pp. 467-470, "A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells".
Iwamoto et al, Science, vol. 238, Nov. 20, 1987, pp. 1132-1134, "YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation".
Saiki et al, British Journal of Cancer, vol. 59, No. 2, Feb. 1989, pp. 194-197, "The Inhibition of Murine Lung Metastasis by Synthetic Polypeptides . . ."

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