Polypeptide comprising repeated cell-adhesive core sequences

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 13, 514 14, 514 15, 514 16, 514 17, 530324, 530325, 530326, 530327, 530328, 530329, 930DIG8, C07K 706, C07K 708, C07K 710, A61K 3702

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051838044

ABSTRACT:
A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:

REFERENCES:
patent: 4929601 (1990-05-01), Brunett et al.
patent: 4988621 (1991-01-01), Ruoslahti et al.
Kunitake et al., Adv. Polymer Sci., 20: 159-211, 1976.
Nishi et al., Int. J. Peptide Protein Res., 30: 275-283, 1987.
Saiki, I. et al., Cancer Research, 49, 3815-3822, Jul. 15, 1989.
EMBO Journal, vol. 4, 1985, pp. 2519-2524, IRL Press Ltd., Oxford, Great Britain, S. Suzuki et al, "Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitro-nectin and fibronectin".
Partial European Search Report of EP 89 11 1468, Nov. 26, 1990.
Humphries et al, Science, vol. 23, Jul. 25, 1986, pp. 467-470, "A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells".
Iwamoto et al, Science, vol. 238, Nov. 20, 1987, pp. 1132-1134, "YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation".
Saiki et al, British Journal of Cancer, vol. 59, No. 2, Feb. 1989, pp. 194-197, "The Inhibition of Murine Lung Metastasis by Synthetic Polypeptides . . ."

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