Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-12-05
2000-12-05
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 14, 514 13, 514 16, 514 12, 530300, 530311, 530313, 530324, 530326, 530327, 530328, 424464, 4241851, A61K 3800, A61K 3900, C07K 500, C07K 700
Patent
active
061567310
ABSTRACT:
There is disclosed a composition containing a biologically active polypeptide selected from LHRH, an LHRH analog, somatostatin and a somatostatin analog, in a therapeutically effective amount, a membrane permeability enhancing agent, and a protease enzyme inhibitor enveloped within an enteric coating. The composition possesses enhanced bioavailability upon oral administration.
REFERENCES:
patent: 4234571 (1980-11-01), Nestor et al.
patent: 4291022 (1981-09-01), Sadrin et al.
patent: 4310518 (1982-01-01), Freidinger
patent: 4342671 (1982-08-01), Sarantakis
patent: 4579730 (1986-04-01), Kidron et al.
patent: 4582820 (1986-04-01), Teng
patent: 4728638 (1988-03-01), Bauer et al.
patent: 4801577 (1989-01-01), Nestor et al.
patent: 4994439 (1991-02-01), Longenecker et al.
M.J. Humphrey and P.S. Ringrose, Drug Metab. Reviews,17: 283-310, (1986).
M.L. Gardner and D. Wood, Biochem. Soc. Trans., 17: 934-937 (1989).
V.V. Mozhaev, I.V. Berezin, K. Martinek, CRC Crit. Rev. Biochem., 23: 235-281 (1988).
H.P. Merkle, Eur. J. Pharm. Sci., 2: 19-21 (1994).
J.A. Fix, J. Pharm. Sci., 85: 1282-1285 (1996).
M. Kidron, H. Bar-On, E.M. Berry, and E. Ziv, Life Sciences, 31: 2837-2841 (1982).
V.H. Lee, Crit. Rev. Ther. Drug Carrier Systems, 5: 69-97 (1988).
O. Siddiqui and Y.W. Chien, Crit. Rev. Ther. Drug Carrier Systems, 3: 195-208 (1987).
M. Saffran et al., Science, 233, 1281 (1986).
M.V. Nekola et al, Science 218, 160 (1982).
N. Yokoo et al., Yakugaku Sasshi, 108(2), 164-169 (1988).
S. Fujii et al., J. Pharm. Pharmacol., 37, 545-549 (1984).
E. Ziv et al., Life Sciences, 29(8), 803-809 (1981).
E. Ziv et al., Biochem. Pharmacol., 36(7), 1035-1039 (1987).
R. Z. Kai et al., Proc. Natl. Acad. Sci. USA, 83, 1896 (1986).
W. Bauer et al., Life Sciences, 31, 1133 (1982).
T. Karashima et al., Life Sciences, 41, 1011 (1987).
T.W. Redding et al., Proc. Natl. Acad. Sci., 80, 1078 (1983).
J.P. Moreau et al., Life Sciences, 40, 419 (1987).
Grass George M.
Sweetana Stephanie A.
Davenport Avis M.
G. D. Searle & Co.
LandOfFree
Polypeptide composition for oral administration does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polypeptide composition for oral administration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide composition for oral administration will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-961822