Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-12-10
1989-03-07
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 21, 530841, A61K 3702, C07K 328
Patent
active
048106917
ABSTRACT:
Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
REFERENCES:
patent: 4455256 (1984-06-01), Urist
Roberts et al, "Transforming Growth Factor Type B: Rapid Induction of Fibrosis and Angiogenisis in vivo and Stimulation of Collagen Formation in vitro", Proc Natl Acad Sci. USA, vol. 83, pp. 4167-4171, Jun. 1986.
Sporn et al, "Transforming Growth Factor-B: Biological Function and Chemical Structure", Science, vol. 233, pp. 532-534, Aug. 1986.
Armstrong Rosa
Bentz Hanne
Ellingsworth Larry
Seyedin Saeid
Thomas Thomas
Collagen Corporation
Kight John
Nutter Nathan M.
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