Polypeptide capable of differentiating and maturing malignant ce

Details Polypeptide capable of differentiating and maturing malignant ce Polypeptide capable of differentiating and maturing malignant ce

1995-03-03

1998-12-08

Achutamurthy, Ponnathapura

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530324, 530399, 930260, 930DIG820, 930DIG800, C07K 412

Patent

active

058470786

ABSTRACT:
A physiologically active polypeptide, BUF-3, having the ability to differentiate and maturate human leukemia cells into normal cells and of accelerating the formation of erythroblasts is disclosed. The polypeptide has a molecular weight of 16.+-.1 Kd as determined by SDS-electrophoresis in the presence of 1% mercaptoethanol, or 25.+-.1 Kd, as determined by SDS-electrophoresis in the absence of mercaptoethanol.

REFERENCES:
patent: 4740587 (1988-04-01), Ling et al.
patent: 4760021 (1988-07-01), Mimura et al.
patent: 4798885 (1989-01-01), Masson et al.
patent: 4973577 (1990-11-01), Vale, Sr. et al.
The Merck Manual, 11th ed. (1966), pp. 77-97.
Nicola et al, Chem. Abs. 102(25), 216019k.
Nagata et al, Chem. Abs. 88(11), 72644C.
Kashiwamura et al, Chem. Abs. 109(25), 223616a.
Chem. Abs., vol. 104, 1986, 953 d.
Nature 321 pp. 724-125, 776-782 (1986).
Nature 318, pp. 659-663 (1986).
Biochem. Biophys. Res. commun. 135, pp. 957-964 (1986).
Chem. Abs. 88 (9)-60952 P.-Okabe et al, (1978), p. 268.
Chem. Abs. 94 (7) -45433a-Bergess et al, (1981), p. 422.
Chem. Abs. 96 (7)-50392g, (1982), p. 456.
Biological Abstracts, No. 77, 1984, No. 517, F. Eithan et al "Modulation of the Maturation of Human Leukemic Promyclocytes to Granulocytes er Macrophages". Midori Juji K.K.
Chemical Abstracts, vol. 100, No. 21, May 21, 1984, p. 485 Abstract No. 172963r; L. Matera et al "Soluble Factor(s) Released by Concanavalin A Activated Lymph Node Lymphocytes Induce Proliferation and Maturation of Chronic Lymphocytic Leukemia . . . ".
Chemical Abstracts, No. 94, No. 17, Apr. 27, 1981, p. 230, Abstract No. 133806e; P.H. Koeffler et al; "Phorbol Ester Effect on Differentiation of Human Myeloid Leukemia Cell Lines Blocked at Different Stages of Maturation".
Chemical Abstracts, vol. 97, No. 19, Nov. 8, 1982, p. 543, Abstract No. 160941p, P. Ralph et al; "Induction of Antibody-Dependent and Nonspecific Tumor Killing in Human Monocytic Leukemia Cells by Nonlymphocyte Factors and Phorbol Ester".

Affiliated with

Also associated with

Rating

Polypeptide capable of differentiating and maturing malignant ce does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptide capable of differentiating and maturing malignant ce, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide capable of differentiating and maturing malignant ce will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-178205