Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2008-05-06
2008-05-06
Szperka, Michael (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S007100, C424S185100
Reexamination Certificate
active
10172573
ABSTRACT:
This invention provides a polynucleotide encoding Repro-EN-1.0 and IB1, polypeptides associated with endometriosis. Auto-antibodies against Repro-EN-1.0 and IB1 have been found in subjects diagnosed with endometriosis. This invention also provides methods of using this polynucleotide and polypeptide.
REFERENCES:
patent: WO94/28021 (1994-12-01), None
Colman, “effects of amino acid sequence changes on antibody-antigen interactions,” research in Immunology, 1994, 145:33-36.
Voorhis et al., J Reprod Immunol, 1997, 33:239-256.
Walter et al., J Autoimmun, 1995, 8:931-45.
Emest24 Database Entry Hs888330 Accession No. W19888; May 5, 1996 Hillier et al.: “The WashU-Merck EST Project” XP002126944.
EMBL Database Entry AI832097 Accession No. AI832097; Jul. 13, 1999 Robert Strausberg XP002141979.
Van Regenmortel, M.,Methods: A Companion to Metohds in Enzymology, 9:465-472, 1966.
El Shami A. Said
French Cynthia K.
Menon Surendra Nath
Mueth, Esq. Joseph E.
Siemens Medical Solutions Diagnostics
Szperka Michael
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