Polypeptide autoantigens associated with endometriosis

Details Polypeptide autoantigens associated with endometriosis Polypeptide autoantigens associated with endometriosis

2008-05-06

2008-05-06

Szperka, Michael (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S007100, C424S185100

Reexamination Certificate

active

07368533

ABSTRACT:
This invention provides a polynucleotide encoding Repro-EN-1.0 and IB1, polypeptides associated with endometriosis. Auto-antibodies against Repro-EN-1.0 and IB1 have been found in subjects diagnosed with endometriosis. This invention also provides methods of using this polynucleotide and polypeptide.

REFERENCES:
patent: WO94/28021 (1994-12-01), None
Colman, “effects of amino acid sequence changes on antibody-antigen interactions,” research in Immunology, 1994, 145:33-36.
Voorhis et al., J Reprod Immunol, 1997, 33:239-256.
Walter et al., J Autoimmun, 1995, 8:931-45.
Emest24 Database Entry Hs888330 Accession No. W19888; May 5, 1996 Hillier et al.: “The WashU-Merck EST Project” XP002126944.
EMBL Database Entry AI832097 Accession No. AI832097; Jul. 13, 1999 Robert Strausberg XP002141979.
Van Regenmortel, M.,Methods: A Companion to Metohds in Enzymology, 9:465-472, 1966.

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