Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Reexamination Certificate
2007-07-26
2009-06-09
Weber, Jon P (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
C530S329000, C530S331000, C530S333000, C530S339000, C514S021800, C514S844000, C514S890000
Reexamination Certificate
active
07544781
ABSTRACT:
A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound (C) represented by formula (3) below, to obtain said polypeptide:(1) X-(Pro-Y-Gly)n-OH, wherein:X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18,Y represents Pro or Hyp, andn denotes an integer of 1 to 20;(2) X-(Z)r—OH, whereinX represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18,Z represents a peptide chain comprising 1 to 10 amino acid residue(s), andr denotes an integer of 1 to 20; and(3) H2N—R—NH2, whereinR represents a linear or branched alkylene group; andfurther wherein the ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %); provided thatin the case where X represents the group HOOC—(CH2)m—CO— and m has the same meaning as defined above in formula (1) and/or (2), the amount of compound (C) is substantially 1 mol relative to 1 mol of the total molar amount of peptide component (A) and/or peptide component (B); andin the case where X represents H in the formula (1) and/or (2), the reaction is conducted without compound (C).
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Kinoshita Hisao
Mikami Hiroshi
Otsuki Chikara
Tanihara Masao
Mohamed Abdel A
PHG Corporation
Weber Jon P
Wenderoth , Lind & Ponack, L.L.P.
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