Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-01-31
2006-01-31
Wax, Robert A. (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C435S320100, C514S012200
Reexamination Certificate
active
06992171
ABSTRACT:
It is intended to construct a screening method, etc. for searching for compounds which are capable of binding to apolipoprotein A-I and thus promote or inhibit the binding of a cubulin fragment to apolipoprotein A-I, and provide preventives or remedies containing compounds obtained by the above screening method, etc. These compounds, etc. are usable in preventives and remedies for various diseases in which cubulin participates and the like.
REFERENCES:
patent: WO 99/37757 (1997-07-01), None
patent: PCT/US011/08631 (2001-03-01), None
Birn, et al. , Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein.J Biol Chem. Oct. 17, 1997;272(42):26497-504.
NCBI, AAC82612, intrinsic factor- from above publication.
Moestrup et al. “The Intrinsic Factor-Vitamin B12 Receptor and Target of Teratogenic Antibodies is a Megalin-binding Peripheral Membrane Protein with Homology to Developmental Proteins” J. Biol. Chem. 273(9):5235-5242 (1998).
Kozyraki et al. “The Human Intrinsic Factor-Vitamin B12 Receptor,Cubilin:Molecular Characterization and Chromosomal Mapping of the Gene to 10p Within the Autosomal Recessive Megalobastic Anemia (MGA1) Region”Blood91(10): 3593-3600 (1998).
Hammad et al. “Cubilin, the endocytic receptor for intrinsic factor-vitamin B12 complex, mediates high-density lipoprotein holoparticle endocytosis” PNAS(USA) 96:10158-10163 (1999).
Kozyraki et al. “The intrinsic factor-vitamin B12 receptor,cublin,is a high-affinity apolipoprotein A-1 receptor facilitating endocytosis of high-density lipoprotein” Nature Medicine 5(6): 656-661 (1999).
Kristiansen et al. “Molecular Dissection of the Intrinsic Factor-Vitamin B12 Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding” J. Biol. Chem. 274(29):20540-20544 (1999).
Kita Shunbun
Taniyama Yoshio
Chao Mark
Mondesi Robert B.
Ramesh Elaine M.
Takeda Pharmaceutical Company Limited
Wax Robert A.
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